MAVS and COVID-19: Indeed, the expression of lysosomal genes was upregulated in blood mononuclear cells of COVID-19 patients [38], while ORF10 and NSP13 of SARS-CoV-2 were reported to suppress type I IFN expression by autophagic degradation of mitochondrial antiviral signaling protein and TANK-binding kinase 1, respectively [23,24].