As IFN-α was found to suppress IL-6/IL-1ß-induced CRP gene transcription and protein production [64,65], it is conceivable that in COVID-19, high levels of antiviral IFN-α one week after diagnosis might contribute to CRP downregulation despite the prolonged increase in CRP-inducing proinflammatory cytokines. This evidence concerns the gene IFNA1 and COVID-19.