MMP2 and pulmonary emphysema: Interestingly, Rogliani and colleagues reported that interstitial fibroblasts present in the areas of parenchymal destruction in emphysema/UIP expressed MMP-2, -7, -9 and membrane-type (MT)-1-MMP with higher, although variable, intensity than in emphysema, which suggested the possible role of these proteases in accelerating the process of destruction and remodeling of emphysema in CPFE patients [53].