VAV1 and neoplasm: GEMMs expressing wild-typeVAV1— The expression of wild-type VAV1 in specific organs, such as the pancreas [81] or the lungs [83] indicated that although the expression of VAV1 alone did not lead to tumor development, the co-expression of VAV1 with mutant KRAS (KRASG12D/VAV1 mice) synergistically enhanced tumorigenesis in these organs [81,83].