In line with this, we found that co-incubation of MetS-MSCs with Vit-C induced hypo-hydroxymethion in genes implicated in regulation of apoptosis, including the NDUFA4 mitochondrial complex associated (NDUFA4), which inhibits apoptosis through B-cell lymphoma 2 and the cytochrome-C-mediated signaling pathway [72]. The gene discussed is COXFA4; the disease is metabolic syndrome.