Finally, the authors demonstrated that TRPA1 expression in breast and lung cancer cells was regulated by NRF2, which can therefore prevent ROS-induced apoptosis by inducing the expression of both canonical (e.g., antioxidant) and non-canonical (e.g., TRPA1) oxidative stress defense proteins (Figure 3) [16,29]. The gene discussed is NFE2L2; the disease is lung cancer.