Moderate ductular reaction in the portal tract areas was already found in 2- and 6-week-old Nf2-mutant mice and progressed in the 20- to 32-week-old cohort, ultimately leading to a massive tumor-like ductular process radiating from and bridging portal areas in livers of 48-week-old Nf2-mutant mice (Figure 2 and Figure S2). The gene discussed is NF2; the disease is neoplasm.