In infants homozygous for the C allele, infant FKBP5 methylation positively correlated with maternal threat-based ACEs and prenatal PTSD symptom severity, but not deprivation-based ACEs or adversity in adulthood, suggesting the type of ACE and allelic variant may affect the epigenetic change associated with symptoms of PTSD [81]. The gene discussed is FKBP5; the disease is post-traumatic stress disorder.