Indeed, we observed significant decreases in MMP-13 expression following the RP-832c treatment, as well as decreases in TGF-β1 and α-SMA tissue expression, which correlated to a reduction in the myofibroblast cells responsible for excessive collagen deposition and tissue remodeling observed in pulmonary fibrosis. The gene discussed is TGFB1; the disease is pulmonary fibrosis.