An SH-SY5Y-derived neuron was chosen because: (1) it has been extensively used for studies related to AD; (2) it expresses GLUT4 as the hippocampal neuron does, and (3) insulin-induced repression of GLUT4 expression and translocation has already been reported in SH-SY5Y cells [61]. The gene discussed is INS; the disease is Alzheimer disease.