MAPT and Alzheimer disease: Moreover, an epigenome-wide study evaluating H3K9ac status in 669 aged human prefrontal cortices uncovers large-scale changes in H3K9ac driven by tau protein in aging and AD human brains; although, AD risk loci were not enriched in tau-associated H3K9ac domains; functional relevance of these chromatin changes was evinced by consistent transcriptional changes in three independent datasets, and similar findings in two mouse models of AD [75].