HDAC9 and Alzheimer disease: Regarding HKac, the overexpression of beta-amyloid in an AD yeast model has been shown to decrease H3K9ac [72], and HDAC inhibition (increasing HK-ac status) was reported to improve the activation of transcription factor EB, promoting lysosome biogenesis, alleviating the pathogenesis of AD in a mouse model of AD [73].