Moreover, interpreting the CREB-regulated transcriptional network is still considerably intricate, since it comprises 17 upregulated ADGs, and also 26 downregulated ADGs, indicating neither the overactivation nor the hypoactivation of the CRE-mediated transcriptional activity; revealing, this way, a widespread deregulation of this signaling pathway in the pathophysiology of AD [70]. Here, CREB1 is linked to Alzheimer disease.