Among the interactors with high proximity, Moesin (Msn) is a protein that was up-regulated in the 5xFAD mice and was observed in microglia in non-demented and AD cells, co-localizing with Aβ in amyloid plaques in AD (late and early onset), as well as in Down syndrome [35,36]. The gene discussed is MSN; the disease is Alzheimer disease.