Similarly, STRING protein network analysis of the dysregulated proteins in 5xFAD revealed high proximity and interaction of proteins that are less mentioned in previous AD proteomics studies (Msn, Cav1, Vtn, Mfge8, Gef, Neto1, Rtn4rl2, Fbs1) with App (Figure S1). Here, RTN4RL2 is linked to Alzheimer disease.