NFE2L2 and hepatocellular carcinoma: To further confirm the effect of SQSTM1/p62 on the migration and invasion of HCC cells, we used the SQSTM1/p62 knockout cell lines (SQSTM1 KO HepG2 cells and SQSTM1 KO2 HepG2 cells) and found that after SQSTM1/p62 knockdown, the expression level of Keap1 was significantly increased (Figure 4A and Figure A3A), while the expression level of Nrf2 was significantly decreased (Figure 4B and Figure A3B).