Furthermore, hematoxylin and eosin staining of the lung (Figure 6D) and liver (Figure 6E) showed that compared with the SQSTM1 WT group, the lung tissue cells in the SQSTM1 KO group were arranged more regularly, the number of tumor cells was decreased, and the degree of deterioration was lower, while no tumor was found in the liver. Here, SQSTM1 is linked to neoplasm.