DNMT-1 is proposed to regulate immune responses, as shown in Graves’ disease [32], whilst Tet methylcytosine dioxygenase 2 (Tet2) deficiency drives hepatic microbiome dysbiosis, leading to CD8+ T cell-mediated autoimmune hepatitis [33]; (iv) N6-methyladenosine (m6A) is a common modification of both mRNA and DNA, whereby the METTL3/METTL14 methyltransferase complex installs m6A onto mRNA, which can impact not only translation, but also nuclear export and decay, as well as pre-mRNA processing, with relevance to immune regulation in T1DM [34]. Here, TET2 is linked to type 1 diabetes mellitus.