PINK1 and Autoimmunity: Overall, the capacity of mitochondria to regulate their oxidant/antioxidant ratio status, including via the induction of the mitochondrial melatonergic pathway, is an important determinant of the association of ‘autoimmunity’ with PINK1 suppression, pro-inflammatory cytokines and mitophagy as well as patterned miRNAs and gene expression (see Figure 2).