LMNA and Hutchinson-Gilford progeria syndrome: We have shown the efficiency of Progerinin on classical HGPS patient-derived fibroblasts and LmnaG609G mice: Progerinin leads to progerin degradation by interrupting Lamin A-progerin interaction and rejuvenates the aging phenotypes of HGPS fibroblasts, which are the increased-senescence and the decreased-proliferation.