Furthermore, since the activation of specific TLR members on the cell surface or in intracellular milieu depend on specific αSyn conformations [100,101,102], associating a single TLR with a specific altered species of synuclein could help expand knowledge on the mechanisms of the synucleinopathies and help the designing of TLR agonists. Here, SNCG is linked to synucleinopathy.