NFKBID and immunodeficiency-centromeric instability-facial anomalies syndrome 1: We speculate that mutations in human nfkbid may underpin some common variable immunodeficiency syndrome (CVID) cases that remain unmapped, and we therefore believe that it is important to characterize its role in B cell development, activation, and differentiation in a model system as CVID patients often have defective responses to encapsulated bacteria [85].