About 853 genes are associated with ALS, of which Single Nucleotide Polymorphisms (SNPs) in Superoxide Dismutase (SOD1), Chromosome-9 orf-72 (C9orf72), Fused in Sarcoma (FUS), and Tar DNA Binding Protein-43 (TDP-43) constitute the majority of familial ALS [5]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.