Correa et al. administered the natural product from the Garcinia Indica fruit garcinol, in combination with a Transforming Growth Factor beta (TGF-β) type 1 receptor inhibitor (TGFβR1I), to wild-type control and Klf11 -/- mice and proved that the two pharmacological agents synergistically regulated Klf11-mediated transcription, as well as inhibited endometriosis progression and lesional human cytochrome P450 3A (CYP3A) expression [68]. The gene discussed is KLF11; the disease is endometriosis.