mRNA Expression of IL-22, IL10RB, CLDN1, CLDN2, CLDN7, CDH1, JAK1, the SNAI1/ZEB1 and ROCK2/MAPK signaling pathways and several CEACAMs was significantly altered in the inflamed colon of IBD patients compared to the healthy mucosa of controls (Figure 8C). Here, CLDN2 is linked to inflammatory bowel disease.