ROCK2 and inflammatory bowel disease: mRNA Expression of IL-22, IL10RB, CLDN1, CLDN2, CLDN7, CDH1, JAK1, the SNAI1/ZEB1 and ROCK2/MAPK signaling pathways and several CEACAMs was significantly altered in the inflamed colon of IBD patients compared to the healthy mucosa of controls (Figure 8C).