Differences in mRNA expression of cell polarity subunits were only observed for Scrib and aPkcz after the third cycle of DSS administration in both wildtype and Muc13−/− mice whereas expression of Ceacam 1, and Tlr4 mRNA was found to be significantly altered upon chronic colitis (Figure 7B and Figures S2 and S3). Here, TLR4 is linked to Chronic colitis.