BAP1 and neoplasm: Moreover, the development of an iCCA was recently reported in a 47 year-old patient without any known CCA risk factors, except for occupational exposure to low levels of asbestos; of note was the fact that the patient carried a BAP1 germline mutation, along with BAP1 loss of heterozygosity in tumor cells, in line with the classical two-hit model of tumor suppressor genes [86].