Our results indicated that compounds in Tualang honey such as luteolin, fisetin, hesperitin, catechin, and kaempferol may have a crucial impact on atherosclerosis through their effects on key biological targets, including PIK3CA, SRC, P1K3R1, EGFR, PTPN11, and AKT1. Here, PTPN11 is linked to atherosclerosis.