PIK3CD and B-cell chronic lymphocytic leukemia: In Burkitt’s lymphoma cells, Q induces autophagic cell death by inhibiting PI3K/AKT/mTOR pathways and partially degrading mutant c-Myc [28], as well as inducing lethal autophagy in chronic lymphocytic leukemia cells through an AKT inhibitor called STL-1 [28,29].