NT5E and cancer: Additionally, the combination of chemotherapy and photodynamic therapy demonstrated a 72.5% tumor inhibition rate, as compared to chemotherapy with laser treatment, which demonstrated 58.7%, and when the combination of chemotherapy and photodynamic therapy was applied in combination with anti-CD73 antibody, the tumor inhibition rate was increased to 93.4%, which inferred that the therapy not only destroyed the cancer cells by generating ROS but also reversed the immunosuppression to elevate the anti-tumor immunity [198].