Here, we analyzed the expression and predictive value of ESPL1/Separase, PTTG1/Securin and PTTG1IP/Securin interacting protein transcript levels in white blood cells of CML patients (n = 97) at the time of diagnosis by means of qRT-PCR. The gene discussed is PTTG1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.