Supplementary Figure S1 shows the major pathway in the KV-treated sample and shows top KEGG pathways enriched in oxaliplatin-resistant AsPC-1 cells such as PI3K-Akt signaling, MAPK, multicellular organism, and metabolism in the cancer pathway (p value < 0.05 (*), 0.01 (**), 0.001 (***)). Furthermore, the RNA-seg result showed that the TMEM139 expression level was highly downregulated in KV-treated oxaliplatin-resistant AsPC-1 cells versus KV-untreated controls (Table 1). Here, AKT1 is linked to cancer.