In a retrospective analysis of The Cancer Genome Atlas HNSCC cohort, it was observed that HPV33-driven HNSCCs have a distinct genomic landscape characterized by a higher rate of aneuploidy, a peculiar immune microenvironment with reduced CD8 T-cell infiltration, and a worse OS compared to HPV16-driven tumors [45]. This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.