MET and neoplasm: Meanwhile, treatment of Dox− CM from 231BrM-Tet-shMet and SKBrM3-Tet-shMet cells significantly increased LY6Ghi/CD11bhi population in mouse neutrophils and knockdown of c-Met attenuated this effect, suggesting c-Met pathway-mediated soluble factors from tumor cells are essential for the maturation of neutrophils (Figure 3A).