Given its unique properties as a PD-L1 mAb, there are several ongoing clinical trials investigating the future role of avelumab in the therapy of CRC (NCT05291156, NCT05289856, NCT04513951, NCT03563157), HCC (NCT05249569), and ICC (NCT04708067, NCT04068194). This evidence concerns the gene CD274 and intrahepatic cholangiocarcinoma.