Dai et al. demonstrated in a series of 90 patients with HCC with high PD-L1 expression in the peritumoral hepatic cells that these patients had a significantly greater risk of metastasis, cancer recurrence, or cancer-related mortality [89], and Semaan et al. demonstrated that high PD-L1 expression in HCC patients was associated with a significantly reduced OS [90]. Here, CD274 is linked to hepatocellular carcinoma.