Moreover, the Forkhead box class O (FoxO) family of transcription factors is composed of FoxO1/FKHR, FoxO3/FKHRL1, FoxO4/AFX, and FoxO6, which regulate cellular homeostasis, autophagy, angiogenesis, tumour growth, and metastasis [66,67,68]. This evidence concerns the gene FOXO4 and neoplasm.