However, some studies have focused on the p62 level in different glial neoplastic samples [119,126,127]; in detail, an increase in p62 expression has been progressively detected from low- to high-grade gliomas with prognostic value, although no correlation with isocitrate dehydrogenase (IDH) mutation status has been documented [119,126,127]. Here, IDH2 is linked to central nervous system cancer.