In particular, the overactivation of the tyrosine kinase receptors, such as the epidermal growth factor receptor (EGFR), the platelet-derived growth factor receptor (PDGFR), and the vascular endothelial growth factor receptor (VEGFR), is responsible for the tumour progression and the resistance to therapy of high-grade gliomas [90,91,92]. Here, KDR is linked to central nervous system cancer.