STAT3 and neoplasm: Furthermore, disruption of the STAT3 signaling axis via genetic ablation of Stat3 in Fsp+ stromal fibroblasts in the KPC PDAC mouse model not only slows tumor progression and increases survival, but also reshapes the characteristic immune-suppressive TME by decreasing M2 macrophages (F480+CD206+) and increasing cytotoxic CD8+ T cells [110].