EGFR and glioblastoma: Very interestingly, by comprehensively studying the complicated molecular interacting networks of hypoxia regulated genes (HRGs-MINW) in GBM, Mao et al. found that CEBPD is a master transcriptional factor for the HRGs-MINW, and ECM mediated activation of EGFR/PI3K is a main down-stream pathway [94], which lends credence to the importance of the ECM niche for GBM.