The association between exosomal EMMPRIN/MMP-2 and ECM degradation was reinforced by zymography assays, demonstrating that secretion of active MMP-2 was activated in primary medulloblastoma cell lines upon coculture with metastatic exosomes enriched with high glycosylated EMMPRIN and MMP-2. Here, MMP2 is linked to medulloblastoma.