In addition, we studied the known CSC markers in ccRCC (CD44, CD133, and CD105), by in vitro immunohistochemistry staining and extrapolation of publicly available datasets like TCGA and CPTAC, with the goal of contributing to the search for novel molecular ccRCC signatures which may lead to diagnostic/prognostic evaluation of patients. The gene discussed is PROM1; the disease is nonpapillary renal cell carcinoma.