In that context, a recent ccRCC model described HIF-1α to be essential for tumour initiation and proliferation by regulating glucose uptake and glycolysis, whereas HIF-2α deletion had only minor effects on tumour development and spread but regulated genes associated with lipoprotein metabolism, ribosome biogenesis and E2F and MYC transcriptional activities [12]. The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.