In that scenario, the dissemination of ccRCC cancer cells leading to a progressive disease can be promoted by the deficit of epithelial cell adhesion molecule E-cad and upregulation of E-cad repressors such as Slug, Snail, ZEB, and TWIST, which are the hallmarks of the EMT process [8]. Here, SNAI1 is linked to nonpapillary renal cell carcinoma.