CDH2 and nonpapillary renal cell carcinoma: However, these data are contrary to another previous study that showed a normal pattern of N-cad expression despite the elevated tumour grades, and patients with N-cad normal expression have a poorer prognosis than those with N-cad abnormal expression, suggesting that N-cad may play a different role in ccRCC and may not be directly associated with the malignant potential of ccRCC [72].