A recent study based on the extrapolation of TCGA data on 533 ccRCC patients showed the classical epithelial marker E-cadherin (E-cad) to be decreased, while the expression of mesenchymal markers N-cadherin (N-cad), SNAI1, vimentin (VIM), TWIST1 to be increased in ccRCC primary tumours, compared to control normal tissues [13]. The gene discussed is TWIST1; the disease is neoplasm.