The representative IHC expression of E-cad in normal adjacent kidney tissue and RCC tumour can be seen in Figure 4A. A comparison of the in-house patient’s normal kidney tissue compared to primary and metastatic tumours by IHC showed the expression of E-cad to be strong in the tubules of normal kidney tissue, slightly diffuse staining in the primary, with no staining in metastatic tumours (Figure 4A). The gene discussed is CDH1; the disease is metastatic neoplasm.