EPAS1 and metastatic neoplasm: Consistent with that, in the CPTAC samples, an insignificant upregulation of HIF-2α protein expression was noted in primary tumours compared to normal kidney tissues (Figure 2B), and that trend of staining was retained in the in-house patient’s primary and metastatic tumours and also in the matching primary and metastatic tumours which showed an enhanced expression of HIF-2α in the metastatic compared to the primary tumours (Figure 2C,D).