The fact that there was no ITGAV expression difference between primary tumours and normal kidney tissues and the ITGAV levels were highest in the lower grade than the higher-grade tumours; high expression of ITGAV has a favourable prognostic significance in ccRCC patients infers ITGAV to be a favourable prognostic marker. This evidence concerns the gene ITGAV and nonpapillary renal cell carcinoma.