We also confirmed, in agreement with previous reports on non-stem CRC cell lines [54,61,62,65], that CSC exposure to F. nucleatum activates Wnt/β-catenin-TCF/LEF signaling, NF-kB transcriptional activity, and a cytokine response selectively involving CXCL-1 and CXCL-8. The gene discussed is HNF4A; the disease is colorectal carcinoma.