NFKB1 and colorectal carcinoma: Along similar lines, Chen et al. used RNA sequencing to identify lncRNA Keratin7-antisense (KRT7-AS) as an F. nucleatum-induced gene in CRC cells; KRT-7 AS up-regulation by F. nucleatum is mediated by the proinflammatory factor NF-kB, and is essential for infection-induced cancer cell migration in vitro and metastasis in vivo [79].