F. nucleatum binding to CEACAM-1 occurs through the trimeric autotransporter adhesin CbpF1 [69], contributing to this microorganism’s T-cell inhibitory action [70]; accordingly, CbpF is sufficient, when recombinantly expressed in E. Coli., to activate the CEACAM-1-phoshotyrosine-ERK axis in CRC spheroids. Here, CEACAM1 is linked to colorectal carcinoma.