To identify whether the slight differences in the sensitivity of some markers influence the performance of the marker panel in the identification of EBER-ISH-positive NPC, the area under the receiver operating characteristic curve (AUC) of a model containing 13 IgA and IgG markers (previously published as antibody risk stratification signature) was calculated based on dichotomized values. The gene discussed is CD79A; the disease is nasopharyngeal carcinoma.