PRICKLE1 and cancer: Among the top five downregulated genes in 4 days pHe 6.6 cells, we find PXDN, coding for Peroxidasin, a heme peroxidase which has been associated with proliferation in endothelial cells [65] and with cancer cells invasive phenotype [66,67], Guanylate Cyclase 1 Soluble Subunit Alpha 2 coding gene (GUCY1A2), which mediates cell growth and survival in different cancer cell types [68,69,70,71,72], and PRICKLE1, prickle planar cell polarity protein 1, a member of the planar cell polarity (PCP) pathway which is involved in cancer cell metastasis [73,74].