TP53 and colorectal carcinoma: Numerous genes are involved in CRC including the tumor suppressors Apc, DCC, p53 and MCC; the oncogenes Kras, SRC, and C-myc; the DNA repair genes hMsh2, hMsh6, hMlh1, hPms1, and hPms2; in addition to CD44 genes and COX-2 [109].