MLH1 and colorectal carcinoma: Several other genes such as tumor suppressors (p53, Itf, Cables1, CpG-island and Tgfβ), mismatch repair (MMR) (Mlh1, Msh2, Msh6 and Pms2), multidrug resistance (Mdr1), autophagy-related (Atg5), trefoil factor family (Tff2), integrin gene (Mac-1), and others (EphB) are either directly involved in the growth of multiple intestinal polyps or CRC in the Apc Min/+ murine model, or indirectly affect this process [115,117].