SP1 and neoplasm: The resulting Sp1-HDAC1 complex deacetylates H3K56 (histone H3 lysine 56), silences FAS and MIR146A genes and upregulates miR-146a targets such as interleukin-1 receptor-associated kinase 1 (IRAK1) and the chemokine receptor CXCR4, and ultimately promotes tumor invasion, proliferation, and survival [62].