While in other solid tumors, an increased number of infiltrating CD163+ M2 macrophages correlates with a worse prognosis and a chemotherapy-induced switch from M2 to M1 in osteosarcomas, thus increasing patient survival, it was mentioned that CD163+ infiltration in CHS is associated with a larger tumor mass, but no correlation between CD163+ TAMs and overall patient survival could be confirmed. This evidence concerns the gene CD163 and osteosarcoma.