The production of the chemokine MCP-1 also demonstrates this unfavorable modulation of the immune system, since the interaction of TAMs can produce this mediator to recruit other monocytes for the microenvironment, and once there, produce inflammatory cytokines (among them IL-1, IL-6, and TNF-α) that end up promoting the tumor progression [49]. The gene discussed is TNF; the disease is neoplasm.