TNF and periodontitis: Thus, by taking into consideration the fact that PCa and periodontitis have similar etiopathogenesis effects, first oral infectious disorders may induce widespread inflammation throughout the body by elevating C-reactive protein (CRP) levels as well as proinflammatory cytokines, such as tumor necrosis factor (TNF), IL-1, and IL-6 levels, which may, in turn, result in prostate inflammation [108].