KDR and lung adenocarcinoma: Moreover, RT-qPCR analysis of VEGFR2 and VEGF-A with MSI2 depletion and overexpression showed that VEGFR2 mRNA is significantly decreased in human lung adenocarcinoma cell lines with MSI2 depletion and increased with MSI2 OE in cell lines with moderate to high VEGFR2 expression (H441, Hcc1171, and Calu-1) (Supplementary Figure S3).