ESR1 and invasive carcinoma: The first patient (case No. 1, Table 3) was a 52-year-old woman with a 1.7 cm ER-positive/HER2-negative, histological grade 2 invasive carcinoma of no special type (IC-NST), who underwent breast-conserving surgery, adjuvant docetaxel, and cyclophosphamide and radiation therapy.