Postmenopausal women with obesity have a 52% increased risk of hormone receptor (HR)-positive breast cancer compared to women with normal weight, and the risk increases to 86% for women with a BMI greater than 35 kg/m2 [4] Postmenopausal women with obesity are also more likely to present with more aggressive and advanced disease at diagnosis, including larger tumors, positive lymph nodes, and regional or distant stage [4]. The gene discussed is NR4A1; the disease is obesity due to melanocortin 4 receptor deficiency.