ERBB2 and obesity due to melanocortin 4 receptor deficiency: However, after breast cancer diagnosis, obesity results in worse overall survival (OS) in all breast cancer subtypes (HR+ HER2- subtype hazard ratio (HR) = 1.39, 95% confidence interval (CI) 1.20–1.62, p < 0.001; HER2+ subtype HR = 1.18, 95% CI 1.05–1.33, p = 0.006; and triple-negative subtype HR = 1.32, 95% CI 1.13–1.53, p < 0.001) [8], and worse OS in both premenopausal (relative risk (RR) = 1.75, 95% CI 1.26–2.41) and postmenopausal women (RR = 1.34, 95% CI 1.18–1.53) [9].