Previous work from our group revealed that the phytocannabinoids cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), and the endocannabinoid anandamide (AEA), are able to induce MCF-7aro cell cycle arrest and modulate aromatase and ERs (ERα and ERβ), the main therapeutic targets in ER+ breast tumors, highlighting their pharmacological potential [38]. Here, ESR1 is linked to breast neoplasm.