The effects of CBD (1 and 5 μM) when combined with AIs Ana, Let, or Exe (10 μM) on the viability of a sensitive ER+ breast cancer cell line, MCF-7aro cells, as well as on a non-tumor cell line, HFF-1 cells, were evaluated for 3 and 6 days. The gene discussed is ESR1; the disease is breast cancer.