Considering that aromatase is one of the main therapeutic targets for the treatment of this type of tumor, and in order to understand the possible involvement of this enzyme on the effects induced by the combinations of CBD (5 μM) with AIs (10 μM) on MCF-7aro cells, their impacts on the protein levels of aromatase were investigated after 3 days of treatment. This evidence concerns the gene CYP19A1 and neoplasm.