SORT1 and central nervous system cancer: Visual observation was confirmed by digital quantification of sortilin staining intensity (Figure 2E), with high sortilin expression in GBM (median h-score = 22.19, IQR 11.52–36.01) compared to glioma grades 1–3 (median h-score = 4.87, IQR 2.24–13.66 p = 0.0016).