Genes encoding transcription factors such as Sox2 and OCT4, lineage-specific regulators such as SHH, WNT, and NOTCH, nuclear hormone receptors such as GR (glucocorticoid receptor), tumor suppressors such as RB1, and oncogenes such as MYC have been shown to interact with various subunits of the SWI/SNF complex [10,104,107,134,135,159,180]. The gene discussed is RB1; the disease is neoplasm.