SMARCA1 and neoplasm: In our previous work, we evaluated AT/RT, which is a tumor with a loss of function (LOF) of SWI/SNF-related matrix-associated, actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1), a core subunit of the SWI/SNF complex, that has a bi-modal age distribution and an aggressive histopathologic appearance but a seemingly unpredictable prognosis [18].