Recently, we found that a locus of HML-6, a heterogeneous but distinct family of elements in the HERV-K superfamily, is overexpressed in highly-invasive GBM cell lines and in patient-derived neurospheres; further, we demonstrated a decrease in survival in samples with elevated expression of the HML-6 protein ERVK3-1 regardless of IDH mutation status [15]. The gene discussed is IDH1; the disease is glioblastoma.