In reviewing the most recent schema, we found that there appeared to be a tendency of tumors with chromatin remodeling defects, especially the SWItch/sucrose non-fermentable (SWI/SNF) complex, to have increased cellular diversity, a predilection for younger populations or a bi-modal age distribution, and dichotomous clinical behavior in CNS tumors [5]. The gene discussed is SMARCA1; the disease is central nervous system neoplasm.