Recent studies have reported that CAFs can sense tumor cell genomic stress by expressing interferon (IFN)-β1, which leads to the increased production of associated factors such as CXC ligand 1 (CXCL1) and CXC ligand 10 (CXCL10), IL-6, IL-8, and IL-11 [23]. This evidence concerns the gene IL6 and neoplasm.