Many studies on gastrointestinal cancers have shown that the upregulation of periostin and HGF is associated with increasing cancer cell malignancy, the elevating of metastatic capacity, and worsening patient prognosis [86,87,88]; thus, it can be said that both periostin and HGF allow dormant cancer cells to reawaken and metastasize. The gene discussed is POSTN; the disease is cancer.