IKZF1 and acute lymphoblastic leukemia: The upregulation of integrins and concomitant increase in adhesion to ECM has been described by a series of studies, e.g., linking increased expression of integrin α5 and α6 to BCR-ABL1 driven ALL [205,232] or linking increased expression of integrin α5 to Ikaros mutations in BCR-ABL1 ALL [206,233].