Of note, adult T cell leukemia/lymphoma exosomes containing miRNAs, VEGF and the oncoprotein Tax alter the behavior of mesenchymal stem cells [252], whereas ALL exosomes containing various miRNAs play a role in the suppression of Th17 cells [253] and in the development of T-ALL cooperating with NOTCH1-signaling [254,255,256]. The gene discussed is VEGFA; the disease is acute lymphoblastic leukemia.