Using mouse 4T1 and human MDA-231BR breast cancer models, Soto et al. (2013) demonstrated an increase in many cell adhesion molecules (CAMs) on the surface of brain endothelial cells, including the Ig superfamily CAMs, VCAM-1 and ICAM-1, as well as VLA-4 and integrin β4 early during breast cancer colonization of the brain. Here, ICAM1 is linked to breast cancer.