Curcumin, the principal curcuminoid found in turmeric, has been shown to inhibit STAT3 activity in multiple cancer types, including lung, renal, gastric, melanoma, pancreatic, ovarian, prostate, colorectal, and breast cancers, resulting in attenuated cell growth both in vitro and in vivo [162,163,164,165,166,167,168,169,170]. Here, STAT3 is linked to melanoma.