From the above results, we observed that 300 nM of AZD1152 treatment reduced the protein levels of phosphor- and total AurB and HPV16E7, as well as increased the level of p53 protein), and knowing that AZD1152 is an anti-tumor agent, we next wanted to study if 300 nM of AZD1152 could activate the apoptotic pathway. The gene discussed is AURKB; the disease is neoplasm.